Adaptive responses of skeletal muscle to intermittent hypoxia

Clanton TL, & PF Klatwitter

J Appl Physiol 90(6):2476-2487, 2001

Low level hypoxia shifts the metabolic enzyme activity of skeletal muscle towards greater aerobic poise, whereas extreme hypoxia shifts metabolism towards greater anaerobic potential. Some conditions of intermittent hypoxia inhibit lactate release during exercise. The net effect of a variety of skeletal muscle adaptive mechanisms to intermittent hypoxia is to preserve contractile function and cell integrity in hypoxia, and translates into improvements in exercise performance.

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